NCE DMPK preclinical Modeling and Simulation (M&S) Expert (all genders)

Posted 16 May 2024

Darmstadt, Hessen - Germany

Req Id 274926

 

Work Your Magic with us!

Ready to explore, break barriers, and discover more? We know you’ve got big plans – so do we! Our colleagues across the globe love innovating with science and technology to enrich people’s lives with our solutions in Healthcare, Life Science, and Electronics. Together, we dream big and are passionate about caring for our rich mix of people, customers, patients, and planet. That's why we are always looking for curious minds that see themselves imagining the unimaginable with us.

United As One for Patients, our purpose in Healthcare is to help create, improve and prolong lives. We develop medicines, intelligent devices and innovative technologies in therapeutic areas such as Oncology, Neurology and Fertility. Our teams work together across 6 continents with passion and relentless curiosity in order to help patients at every stage of life. Joining our Healthcare team is becoming part of a diverse, inclusive and flexible working culture, presenting great opportunities for personal development and career advancement across the globe.

 


Your role:

New Chemical Entities Drug Metabolism and Pharmacokinetics (NCE DMPK) preclinical M&S expert is a scientific and strategic role in pharmaceutical Research and Development. Merck Healthcare is committed to bringing transformational medicines to patients, and you will collaborate in a matrix environment with other passionate functional experts to bring forward novel therapeutics. In this role, you will be responsible for delivering PK and PK/PD modelling to support the optimization and selection of drug candidates in preclinical projects of various modalities, including small molecules, PROTACs as well as payloads for antibody drug conjugates (ADCs). You will devise the PK/PD strategy and use M&S to support the design of in-vitro and in-vivo pharmacology studies. You will predict human PK characteristics of drug candidates based on in-vitro and in-vivo preclinical data to estimate human efficacious exposure and dose. Quantitative predictions of drug-drug-interactions of drug candidates employing appropriate PBPK modelling is also within the scope of the role.

We are looking for an individual with a proven track record of applying modelling and simulation approaches to biological problems and ideally experience in quantitative pharmacology & pharmacokinetics.

The NCE DMPK preclinical M&S expert is a member of the Discovery Project Team, depending on the phase of the project. As scientific matter expert, you represent the NCE DMPK function ensuring proper flow of information between the project, the function, and key stakeholders. You will also contribute to / lead scientific initiatives designed to improve the M&S capabilities within our drug discovery organization.

 

Who you are:

  • Education in either Pharmacokinetics, Pharmaceutical/ Biotechnological Sciences, Biomedical/Chemical Engineering, Applied Mathematics, or a related discipline.

  • Master’s degree with ≥5 years in pharmaceutical/biotechnological industry or Ph.D./Post-Doc preferably with experience in in pharmaceutical/biotechnological industry

  • Comprehensive understanding of the concepts of pharmacokinetics and pharmacodynamics during drug discovery & development

  • Strong hands-on experience with modeling software (such as: MatLab, R, Phoenix/WinNonlin, NONMEM, Monolix etc).

  • Experience with the application of PBPK models to support ADME (Simcyp, Gastroplus, PK-Sim).

  • Experience with DDI predictions using appropriate static and dynamic approaches is desirable.

  • Experience in Python, C/C++ and/or other programming languages would be advantageous.

  • Good understanding of related disciplines (pharmacology, toxicology, nonclinical safety, drug design, bioanalytics, etc.) is desirable.

  • Fluent spoken and written English, German is a plus.

 



What we offer: We are curious minds that come from a broad range of backgrounds, perspectives, and life experiences. We celebrate all dimensions of diversity and believe that it drives excellence and innovation, strengthening our ability to lead in science and technology. We are committed to creating access and opportunities for all to develop and grow at your own pace. Join us in building a culture of inclusion and belonging that impacts millions and empowers everyone to work their magic and champion human progress!
 
Apply now and become a part of our diverse team!

Apply Now