Research Associate - Cell Culture

Posted 03 May 2019

Billerica, Massachusetts - United States

Req Id 191710

Details

 

A career with EMD Serono is an ongoing journey of discovery: our 51,000 people are shaping how the world lives, works and plays through next generation advancements in healthcare, life science and performance materials. For more than 350 years and across the world we have passionately pursued our curiosity to find novel and vibrant ways of enhancing the lives of others. EMD Serono is a business of Merck KGaA, Darmstadt, Germany.

 


Your role:

At EMD Serono, the Supply Operations group, a core function that generates micrograms to grams of purified proteins, is seeking a motivated researcher to join our recombinant protein expression team. The Research Associate will be responsible for small and large scale expression of therapeutic and reagent proteins, primarily by transient transfection of mammalian cells lines, or from stable cell lines 

  • Protein expression/production from mammalian cell cultures to support preclinical discovery research.  Cell lines include HEK, CHO and hybridomas.
  • Cell line maintenance and cell passage; Research cell banks creation.
  • Perform medium- to high-throughput transient gene expression in HEK and CHO cells
  • Generate stable mammalian cell lines: Perform stability studies and select highly expressing cell lines for cell banking and protein production.
  • Perform scale-up fed-batch bioreactor processes.  Evaluate and implement optimal feeding strategies to improve product yield, quality and purity.
  • Generate, manage, evaluate, and maintain critical data in a highly organized manner.  Provide reports and prepare scientific presentations as needed.  Write/revise SOPs and technical reports.
  • Focus on continuous process improvement and implement new technology/innovations wherever possible.
  • Collaborate and coordinate with colleagues from design and cell line development teams, downstream purification and analytical development groups.
     

Who you are:

Minimum Qualifications:

  • Bachelor’s degree in Biology, Biochemistry, Molecular Biology or related Science discipline; Associate’s degree in Biology, Biochemistry, Molecular Biology or related Science discipline with 1+ year’s experience in mammalian cell culture operations, or HSD/equivalent with 5+ year’s’ experience in mammalian cell culture operations
  • 1+ year’s experience of mammalian cell culture and protein expression systems
  • 1+ year’s experience handling and manipulating mammalian cell lines aseptically

 

Preferred Qualifications:

  • Bachelor’s degree in Biology, Biochemistry, Molecular Biology or related Science discipline with 2+ year’s experience in mammalian cell culture and protein expression systems.
  • Background in transient transfection in HEK 293 and CHO cells and in establishing stable CHO cell lines (pools, clones) expressing high levels of the protein of interest is preferred.
  • Familiarity with bioprocess monitoring tools and equipment.
  • Ability to critically analyze data using standard statistical and computational tools and to compile technical reports.
  • Knowledge of standard protein analytical techniques such as SDS-PAGE, ForteBio/Octet.
  • Ability to manage multiple independent projects and complexity within a timeline driven environment.
  • Ability to work well within a team and to effectively communicate with others.
  • Experience in the pharmaceutical or biotechnology industry is desired.
  • Excellent written, oral and collaborative skills.

RSREMD


What we offer: With us, there are always opportunities to break new ground. We empower you to fulfil your ambitions, and our diverse businesses offer various career moves to seek new horizons. We trust you with responsibility early on and support you to draw your own career map that is responsive to your aspirations and priorities in life. Join us and bring your curiosity to life!

Curious? Apply and find more information at https://jobs.vibrantm.com

 



The Company is an Equal Employment Opportunity employer. No employee or applicant for employment will be discriminated against on the basis of race, color, religion, age, sex, sexual orientation, national origin, ancestry, disability, military or veteran status, genetic information, gender identity, transgender status, marital status, or any other classification protected by applicable federal, state, or local law. This policy of Equal Employment Opportunity applies to all policies and programs relating to recruitment and hiring, promotion, compensation, benefits, discipline, termination, and all other terms and conditions of employment. Any applicant or employee who believes they have been discriminated against by the Company or anyone acting on behalf of the Company must report any concerns to their Human Resources Business Partner, Legal, or Compliance immediately. The Company will not retaliate against any individual because they made a good faith report of discrimination.

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